It is with immense pleasure, the organizing committee of "Metabolomics Conference 2017" welcomes participants from all over the world to join this prestigious event to be held during August 29-30, 2017 at Prague, Czech Republic. The conference includes keynote presentations, oral presentations / displays exhibitions.
Metabolomics is principally the logical study of the metabolites. In detail, metabolomics is a study of distinctive chemical thumbprints that are left behind by specific cellular processes, the study of their metabolites profiles of small molecules. Metabolome is a pool of all the metabolites in a biological cell, tissue, or body, which are the final products of cellular processes. mRNA expression data of genes and proteomic analyzes reveal all the gene products are produced in the cell, data representing an aspect of cellular function. Conversely, metabolic profiling can give an overview of the physiology of the cell. One of the challenges of functional genomics and systems biology is to integrate proteomics information, transcriptomics and metabolomics to provide a better understanding of cell biology.
The conference is focused mainly on the progress and the most recent models displaying metabolomics, proteomics, genomics, precision medicine, systems biology, Lipidomics, LC-MS and GC-MS techniques, bioinformatics, metabolomics plants, clinical metabolomics, the tumor and the digestive system, computational science, blurred metabolomics, metabonomics nutrition, therapeutic metabolomics and more. Metabolomics is the enthusiasm of the physicians in the light of the fact that this could encourage improvements to the conclusion and human disease medicines. Metabolomics as a command makes use of systematic processes, for example, chromatography, spectroscopy, and the multivariate investigation. Metabolomics allows researchers to measure the physiological impacts and detect adverse to calm responses.
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In metabolomics, real endeavours are put resources into the advancement of suitable scientific methodologies. Metabolites includes a diverse group of low-molecular-weight structures such as lipids, nucleic acids,amino acids, peptides, vitamins, organic acids, thiols and carbohydrates, which makes global analysis a big challenge. The recent development of analytical platforms, such as GC, HPLC, UPLC, CE coupled to MS and NMR spectroscopy, enables separation, detection, characterization and quantification of these metabolites and other related metabolic pathways. Because of the complexity of the metabolome and diverse properties of the metabolites, single analytical platform cannot be used for detecting all metabolites in a sample. The combined use of modern instrumental analytical approaches has led to the ideal outcomes, and is important for increasing the coverage of metabolites which cannot be achieved by single-analysis techniques. Integrated platforms are frequently being used for providing sensitive and reliable detection of thousands of metabolites in a bio fluid sample. Continued development of these analytical platforms will accelerate widespread use and integration of metabolomics into systems biology.
Lipids are the important participant in control and regulation of cellular function. The diversity of chemical structure of these lipids is a major challenge for managing high volumes of complex data. The need for bioinformatics is to manage and integrate the experimental data in various aspects, such as, for lipid classification, ontologies, database design, analysis, and visual display. They play diverse roles in human physiology. Lipidomics is a growing field with numerous applications. For analysing different cell types ESI mass spectroscopy is used. Identification of lipid composition and quantification of cellular lipids gives us details about the lipid related pathway which also helps in identification of metabolic pathways and the effected enzymes.
Application of metabolomics in the field of cancer research has led to appreciation of metabolism in development of cancer and its progression. This has also led to the discovery of metabolite cancer biomarkers and even identifying a number of novel cancer causing metabolites. Cancer is a metabolic disease which changes the digestion system of the cell and encompassing milieu. Metabolomics in field of pharmaceuticals is turning into an inexorably mainstream instrument for life sciences as it is generally quick and also precise procedure which can be connected with either a specific centre or in a worldwide way to uncover new learning about organic frameworks.
Metabolomics is the powerful systems biology approach. An important feature of metabolomics is its ability to underpin complex metabolic interactions of host and microbial partners. The technology of metabolomics is enough for adding up the analytical strategies presently at disposal of clinical experts.
Metabolomics research like any other high throughput technology generates a large amount of data. Handling and analysis of results is one of the biggest bottlenecks in the workflow. Metabolomics data requires intense pre-processing, analysis, normalization and mining procedures. Suitable data mining procedures are to be applied in order to extract maximum information from the research.
Mass spectroscopy and NMR are the major pillars on which metabolomics and metabolite profiling are based. Both techniques have their own advantages and disadvantages, but both provide complementary information for analytical scientist. Mass Spectroscopy is the production and detection of ions separated according to their mass to charge ratio. MS analysis has gained lot of popularity for its use in glycosylated protein analysis because of its high selectivity, sensitivity and ability of analysing complex mixtures rapidly.
Metabolites are intermediates and also products of metabolism. Metabolites and numerous structure, functions including fuel, signalling, stimulatory and inhibiting effect on enzymes, catalytic activities, interaction and defense. Metabolite identification remains to be bottleneck in MS- based Metabolomics.
Metabolomics is being utilized across Drug Discovery and development from lead compound discovery to post approval drug surveillance. Diseases results in metabolic changes. These changes are the cause of disease progression. By identifying metabolic changes metabolomics can help in finding potential new sites for therapeutic intervention. Metabonomics refers specifically to the analysis of metabolic responses to various drugs or diseases. Metabonomics has become a major area of research; it is the more complex biological study, used as a method for identifying biomarkers for various disease. In general, in most disease cases, a metabolic pathway has been either activated or deactivated. This parameter is used as a marker for certain diseases. For instance Serotonin production pathway is activated in a person who has recently consumed alcohol, and thus can be a metabolic marker for recent alcohol consumption.
Metabolomics is a data intensive discipline thus its workflow is characterized by extensive use of databases. Database applications range from compound identification to data integration and visualization. The work of individual labs and consortiums round the globe has established independent databases containing accurate information on numerous metabolites. They serve the primary purpose of organizing information on the large catalogue of metabolites that are encountered in metabolism pathways.
Human health is the level of functional and metabolic efficiency of an individual. Personalised medicine is the ultimate customisation of healthcare and requires metabolomics for quick medical diagnosis for identifying disease. In healthcare, use of classical biochemical tests is for measuring individual metabolite concentrations in order to identify disease states like the blood-glucose level in the case of diabetes. Metabolomics has the potential for the rapid identification of metabolites and identify the states of these diseases much earlier.
Rapid advances are made in prediction, detection, understanding and monitoring of the human disease using metabolomic technologies. Metabolomics is connected to research a few human illnesses for enhancing their determination and aversion and to outlining better systems. Metabolomic profiling is utilized for distinguishing novel biomarkers and mechanisms of cardio disease risk in diabetes research. Metabolomics is used for investigating several diseases for improving their diagnosis and prevention and also for designing better therapeutic strategies.
Metabolomics is the study of substrates and products of metabolism that are influenced by genetic as well as environmental factors. Metabolomics is a powerful approach as metabolites and their concentration directly reflect biochemical activity and the state of cells. Thus, metabolomics represent the best molecular phenotype. The close relation with phenotype makes it an ideal tool for Healthcare, Pharmaceutical, agriculture industries and others. Metabolomics is study of the unique chemical fingerprints which are left behind by specific cellular processes. It is for understanding biological systems and prediction of their behaviour, through the profiling of metabolites. The measurement and interpretation of the metabolite profile from a biological sample (typically urine, serum, or biological tissue extract) provides number of opportunities for investigating changes induced by external stimuli (e.g. drug) and also add up our knowledge of inherent biological variation within sub populations.
Pathway is a series of reactions converting set of substrate into set of products within a living cell. It is important to assess the inherent network properties in a biochemical reaction network. A typical genome scale metabolic network contains one thousand reactions/ metabolites. Metabolic pathway analysis for large, complex metabolic networks is often leads to combinatorial explosion.
Metabolic syndrome is a group of risk factors that raises the risk for heart diseases and other health issues, such as diabetes and stroke. The term "metabolic" refers to biochemical processes which are involved in the normal functioning of the individual. Risk factors include traits, habits, or conditions which increases the chance of developing a disease. Risk of heart diseases, stroke and diabetes increases along the number of metabolic risk factors. The risk of having metabolic syndrome is very closely linked to obesity and overweight and also lack of physical activity. Metabolic syndrome is becoming common due to the rise in obesity rate. In the near future, metabolic syndrome may overtake smoking as one of the leading risk factor for heart disease. It is possible to prevent metabolic syndrome, with lifestyle changes. A healthy lifestyle is a definitely a lifelong commitment. Successfully controlling metabolic syndrome needs long-term effort and also teamwork with health care providers.
Metabolomics is a powerful tool in drug discovery and metabolic engineering. Along with these strengths, the field plays an important role in Systems biology research, which in turn is transforming the practice of medicine, our ability to engineer living organisms.. Systems biology is the quantitative study of an individual, which is a complex web of interchanging and interacting molecular participants, and even their environment.
NMR spectroscopy is the leading technology used for measuring metabolite levels. It is an approach that can be applied to solid as well as liquid samples which are either in vitro or in vivo. Two strategies for analysis of NMR metabolic data are the traditional ‘fingerprinting’ based on intact NMR spectrum. The other is for analysis of NMR data .i.e. ‘Profiling’ which uses computational methods for obtaining the list of metabolites and their concentration.
Nutrigenomics is research focusing on identification and understanding of molecular-level interaction between dietry bioactives and nutrients with the genome. It is the research associated with the idea of personalized nutrition based on genotype for providing people with methods and tools for preventing disease and health promoting foods to match their lifestyles, cultures and genetics. It is a science still in its infancy and its contribution to public health in the next decade is thought to be major. Nutrigenetics is the science of how the whole body responds to food with help of systems biology research.
Characterisation of interactions of organisms with their environment is Environmental metabolomics. The advantage of studying organism is for environment interactions, assessing organism function and health at the molecular level. The increasing number of applications in the environmental sciences range from understanding organismal responses to abiotic pressures, to investigating the responses of organisms to other biota. The rapid growth in environmental metabolomics is the result of rapid nature of non-targeted metabolomics and even the ability to generate hypotheses involving complex environmental stressors, especially when the mode of action is unknown.
One of the biggest challenges of systems biology and functional genomics is integration of Transcriptomic, Proteomic and metabolomic data in order to provide a better understanding of cellular biology. Transcriptome can be seen as the precussor to Proteome. Proteomics analyses the structure and function of organism. Whereas Transcriptomics is the study of the complete set of RNA Transcripts that are delivered by the genome under particular circumstances. The technology and software are still evolving and mapping the human proteome and metabolome.
Steroids are based on the cyclopentanoperhydrophenanthrene structure and belong to isoprenoid family, and abnormalities in their synthesis is related to numerous diseases. Mostly steroid hormones are ligands to nuclear receptor and mutations in receptor and may change its ligand specificity resulting in allowing them for binding to other steroids, and thus physiological changes. This track will concentrate on analysis of steroids.
21. Systems Biology
Systems biology is the mathematical and computational modelling of biological components, which may be molecules, cells, organisms or entire species. Living systems are complex and dynamic, and their behavior is difficult to predict from the properties of individual parts. For studying all these, quantitative measurements of the behavior of groups of interacting components are used and also technologies such as genomics, bioinformatics, proteomics, mathematical and computational models are used for describing and predicting dynamical behavior.
Metabolomics is the science of studying chemical processes of metabolites. It basically involves the use of analytical techniques such as chromatography, spectrometry, NMR, and capillary electrophoresis. It is extensively used in pharmaceutical and biotechnology industries for biomarker and drug discovery. Over last few decades, there has been a tremendous development in biochemistry and molecular biology which had a positive impact on metabolomics market. The global market for metabolomics was valued at $712 million in the year 2012 and is expected to reach nearly $1.4 billion in the year 2017, after increasing at a five-year CAGR of 14.2%. North America is the market leader with a share of approximately 42% of the market, followed by Europe with a share of approx. 38%. Also Asia-Pacific region represents significant growth opportunity for the metabolomics market during of 2014 to 2019. The APAC market is expected to grow at a CAGR of 23% during 2014-2019. The growing pharmaceutical and biotechnology industries are driving the growth of this market. The Global Metabolomics Market is segmented on the basis of Technique (Separation and Detection Techniques), Applications (in Agriculture & Environmental Industries, Toxicology Testing, Personalized medicine and Biomarker discovery) and also Region (USA, Europe, APAC and Rest of the World).
Why Czech Republic?
The European market is becoming the growth centre for the global market. Czech Republic is one of the most advanced and developed European economy is bound to hold chief share of metabolomics and Systems biology research. The metabolomics market Europe is showing a significant growth during the forecast period of 2014 to 2019. A higher CAGR in these markets is specifically attributing to the growing demand for personalized medicine, need for toxicology testing, and also increase in research funding from the respective governments and private investors. Europe is considered to be one of the largest markets after US because of its good infrastructure facility and increase in research.
Why to attend?
Metabolomics is an emerging and promising field among many biological areas of application as metabolite levels changes with developmental, physiological and pathological state. It is sensitive to both genetic and modifying environmental influences that determine the metabolic fingerprint of an individual. Metabolomics Conference 2017 provides a platform to meet top notch experts in the field of metabolomics, systems biology, proteomics, transcriptomics, precision medicine & molecular biology to discuss molecular mechanisms by which genetic information is encoded in DNA. It would be a great opportunity for companies that are dealing in analytical instruments required for this field. It will also be benefitting to the students, researchers, scholars and others participants who will be participating in the world class international workshops, symposia and exhibition which will be directed by specialists in particular field.
Major Metabolomics Related Associations around the Globe:
- Metabolomics Society
- American association for the advancement of science
- American association for clinical chemistry
- American association for cancer research
- American association of pharmaceutical scientists
- Association for Consumer Research (ACR)
- American cancer society
- Bioinformatics society of India
- Nutrigenomics Organization
- The British Society for Genetic Medicine
- The Genetics Society
- Netherlands metabolomics center
- The Australian biotechnology association
- Human Proteome Organization
- Indiana Proteomics Consortium
- Proteome Society
- European federation of biotechnology
- Australasian Proteomics Society
- Clinical Genetics Society
Major Metabolomics Related Research Units in Europe:
- Netherland’s Metabolomics centre
- University of Luxembourg
- Cardiff University
- Centre for Genomic regulation
Major Companies related to Metabolomics:
- Danaher Corporation
- Bruker Corporation
- Waters Corporation
- Metabolon, Inc.
- Agilent Technologies
- Thermo Fisher Scientific
- Shimadzu Corporation