Metabolomics and Drug Discovery
Metabolomics is being utilized across Drug Discovery and development from lead compound discovery to post approval drug surveillance. Diseases results in metabolic changes. These changes are the cause of disease progression. By identifying metabolic changes metabolomics can help in finding potential new sites for therapeutic intervention. Metabonomics refers specifically to the analysis of metabolic responses to various drugs or diseases. Metabonomics has become a major area of research; it is the more complex biological study, used as a method for identifying biomarkers for various disease. In general, in most disease cases, a metabolic pathway has been either activated or deactivated. This parameter is used as a marker for certain diseases. For instance Serotonin production pathway is activated in a person who has recently consumed alcohol, and thus can be a metabolic marker for recent alcohol consumption.
- Applications in drug development
- Drug metabolism during drug design and development
- Metabolites in identification of drug targets
- Metabonomics in preclinical pharmaceutical discovery and development
- Toxicology and drug metabolism