Global assembling of Academicians, Researchers, Scholars & Industry to disseminate and exchange information at 100+ Allied Academics Conferences

The University of Texas, USA
Title: Evaluating heme flux and function in lung cancer

Li Zhang completed her PhD from UCLA and postdoctoral studies from MIT department of Biology. She is the Cecil H. and Ida Green Distinguished Chair in Systems Biology Science at the University of Texas at Dallas. Professor Zhang’s laboratory has worked on studying heme signaling and function for 20+ years. She has published many original research articles and a book entitled “Heme Biology: The Secret Life of Heme in Regulating Diverse Biological Processes” on this subject. Professor Zhang’s laboratory has also made important contributions in understanding the roles of molecular chaperones in cellular signaling, molecular mechanisms of oxygen signaling, and the actions of neurotoxicants. Recently, Professor Zhang’s lab focuses on investigating heme function in lung cancer. She and colleagues have provided a unifying view of cancer bioenergetics in a review article entitled “A Holistic View of Cancer Bioenergetics: Mitochondrial Function and Respiration Play Fundamental Roles in the Development and Progression of Diverse Tumors,” published in the journal “Clinical and Translational Medicine.”


Emerging experimental data increasingly show that despite the enhanced glycolytic flux, many types of cancer cells exhibit intensified oxygen consumption or mitochondrial respiration. Even under hypoxia, cancer cells can maintain oxidative phosphorylation at a substantial rate. Heme is a central factor in oxygen utilization and oxidative phosphorylation. It serves as a prosthetic group in many proteins and enzymes involved in mitochondrial respiration. Our recent work showed that non-small-cell lung cancer (NSCLC) cells and xenograft tumors exhibit substantially increased levels in an array of proteins promoting heme synthesis, uptake and function. These proteins include the rate-limiting heme biosynthetic enzyme ALAS, transporter proteins, and various types of oxygen-utilizing hemoproteins, such as cytoglobin and cytochromes. In contrast, lowering heme biosynthesis and uptake, like inhibiting mitochondrial respiration, effectively reduced oxygen consumption, cancer cell proliferation, migration and colony formation. To further ascertain the importance of elevated heme flux and function in lung tumorigenesis, we use multiple experimental approaches to detect the levels of heme synthesis, uptake, and degradation in an array of NSCLC cell lines and in de novo tumors in genetically engineered mouse models for lung cancer. We also measure oxygen consumption and ATP generation in these cell lines and tumors. These experiments should reveal the degree to which elevated heme flux—heme synthesis, uptake, and degradation—contribute to lung tumorigenesis and how heterogeneity in heme flux contributes to metabolic and bioenergetics heterogeneity in lung tumors.

Special Issues
All accepted abstracts will be published in respective Allied Academies Journals.
Abstracts will be provided with Digital Object Identifier by

Allied Academies Global Conference Directory

Mail us at

Drop us an email for Program enquiry
Sponsors / Exhibiting / Advertising
General Queries
More details about

Terms and Conditions

Cancellation, Postponement and Transfer of Registration

All cancellations or modifications of registration must be made in writing to

Cancellation Policy

If  Allied Academies cancels this event for any reason, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies event which must occur within one year from the date of cancellation.


If Allied Academies Ltd postpones an event for any reason and you are unable or unwilling to attend on rescheduled dates, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies event which must occur within one year from the date of postponement.

Transfer of registration

All fully paid registrations are transferable to other persons from the same organization, if registered person is unable to attend the event. Transfers must be made by the registered person in writing to Details must be included the full name of replacement person, their title, contact phone number and email address. All other registration details will be assigned to the new person unless otherwise specified.

Registration can be transferred to one conference to another conference of Allied Academies if the person is unable to attend one of conferences.

However, Registration cannot be transferred if it is intimated within 14 days of respective conference.
The transferred registrations will not be eligible for Refund.

Visa Information

Keeping in view of increased security measures, we would like to request all the participants to apply for Visa as soon as possible.

Allied Academies will not directly contact embassies and consulates on behalf of visa applicants. All delegates or invitees should apply for Business Visa only.

Important note for failed visa applications: Visa issues cannot come under the consideration of cancellation policy of Allied Academies, including the inability to obtain a visa.

Refund Policy:

If the registrant is unable to attend, and is not in a position to transfer his/her participation to another person or event, then the following refund arrangements apply:

Keeping in view of advance payments towards Venue, Printing, Shipping, Hotels and other overheads, we had to keep Refund Policy is as following slabs-
  • Before 60 days of the conference: Eligible for Full Refund less $150 service Fee
  • Within 60-30 days of Conference: Eligible for 40% of payment Refund
  • Within 30 days of Conference: Not eligible for Refund

Accommodation Cancellation Policy:

Accommodation Providers (Hotels) have their own cancellation policies, and they generally apply when cancellations are made less than 30 days prior to arrival. Please contact us as soon as possible, if you wish to cancel or amend your accommodation. Allied Academies Ltd will advise the cancellation policy of your accommodation provider, prior to cancelling or amending your booking, to ensure you are fully aware of any non-refundable deposits.

Authorization Policy

Copyright © 2018-2019 Allied Academies, All Rights Reserved.